Aptamer modified Ti3C2 nanosheets application in smart targeted photothermal therapy for cancer

Abstract Background Ti 3 C 2 is a type of transition metal carbides and nitrides (MXenes) with high light-to-heat conversion efficiency property, which has been widely used in cancer treatment recently. In fact, active targeting delivery MXenes nanomaterials molecule could enhance the therapeutic efficacy. However, targeted therapy not further studied past. Aptamers (Apt) excellent affinity specificity properties have as tools. Predictably, incorporation Apt into will offer an unprecedented opportunity research fields therapy. Results Transmembrane glycoprotein mucin 1 (MUC1) overexpressed on surface MCF-7 cells, MUC1 (Apt-M) target cells specificity. Here, smart nanotherapeutic system /Apt-M was fabricated, specifically recognize enter cells. Benefitting from desirable performance Apt-M, completed ingestion process /Apt-Mf nanosheets within 4 h, Apt-M facilitated entry Besides, exhibited potential outstanding photothermal agent (PTA) because inherited wrapped nanosheets. As demonstrated, upon 808 nm laser irradiation, displayed satisfactory antitumor effect by both vitro vivo. Conclusion This study provides new idea for development performance. Graphical